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Nitric oxide then activates the enzyme guanylate cyclase, which leads to improved amounts of cyclic guanosine monophosphate (cGMP), generating smooth muscle rest while in the corpus cavernosum and enabling inflow of blood .
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Sickle-cell anemia (blood condition)—Sildenafil must be utilised with caution in these people as issues with prolonged erection of your penis may well take place.
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These medicines prevent an enzyme referred to as phosphodiesterase style-five from Performing much too immediately. The penis is amongst the locations the place this enzyme is effective.
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